Cross-references to external classification systems

Many Gene Ontology terms are cross-referenced to corresponding concepts from a number of external vocabularies, including Enzyme Commission numbers, KEGG, Reactome Pathways, and Wikipedia. Please report any errors or suggest alternatives to the GO helpdesk.

Using and citing cross-references and mappings

If you have used a mapping in a publication or presentation, please ensure that you cite both the GO knowledgebase and the source of the mapping (detailed below). See the GO citation guide for citing the GO knowledgebase.

Cross-references format

Header describing the date generated and the GO release used, for example:

! Generated on 2018-10-05T08:40Z from the ontology 'go' with data version: 'releases/YYYY-MM-DD'
Each cross-reference is on a different line, in the format:

database:term identifier (id/name) > GO:GO term name ; GO:id

For example:

EC:1.1.1.1 > GO:alcohol dehydrogenase (NAD) activity ; GO:0004022
Note that cross-references to GO mappings can be many-to-many.

Mappings file directory

Direct access to the mappings file directory is available here: https://current.geneontology.org/ontology/external2go/.

Cross-references maintained by the GO Consortium

Those cross-references are maintained by GO editors. Please report issues in the GO GitHub tracker.

Mapping	Entities mapped	Direct access to mapping file
EC: Enzyme Commission	EC numbers	ec2go
EAWAG-BBD	Enzymes	um-bbd_enzymeid2go
EAWAG-BBD	Pathways	um-bbd_pathwayid2go
EAWAG-BBD	Reactions	um-bbd_reactionid2go
KEGG: Kyoto Encyclopaedia of Genes and Genomes	Pathways and reactions	kegg_reaction2go
MetaCyc	Pathways and reactions	metacyc2go
Reactome	Events and catalyst activities	reactome2go
Rhea	Biochemical reactions	rhea2go

Cross-references maintained by external groups

Note: Those files are regenerated during the bi-monthly UniProtKB-GOA release. Please report issues in the GO GitHub tracker.

Mapping	Direct access to mapping file
HAMAP: High-Quality Automated and Manual Annotation of Microbial Proteomes - Families Maintainted by the UniProtKB team PMID:18849571	hamap2go
InterPro - Protein families, domains and functional sites Maintainted by the InterPro team PMID:18940856	interpro2go
Pfam domains Maintainted by the InterPro team PMID:18940856	pfam2go
PIRSF - Protein superfamilies Maintainted by the InterPro team PMID:18940856	pirsf2go
PRINTS - Domains Maintainted by the InterPro team PMID:18940856	pirsf2go
ProDom - Domains Maintainted by the InterPro team PMID:18940856	prodom2go
ProSite - Domains Maintainted by the InterPro team PMID:18940856	prosite2go
Rfam - RNA families	rfam2go
SMART - Domains Maintainted by the InterPro team PMID:29040681	smart2go
UniProt Keywords Mapping of GO terms to UniProt Knowledgebase keywords. Maintainted by the UniProt and UniProtKB-GOA PMID:25378336	uniprotkb_kw2go
UniProt Subcellular location Mapping of GO terms to UniProt Subcellular location terms. Maintainted by the UniProt and UniProtKB-GOA PMID:25378336	uniprotkb_sl2go
UniRules Mapping of GO terms to UniProt Subcellular location terms. Maintainted by the UniProt team	unirule2go

Archived cross-references

Mapping	Last update	Direct access to mapping file
COG - Functional categories Clusters of Orthologous Groups (COG) Constructed by Michael Ashburner and Jane Lomax	June 2004	cog2go
EGAD: Expressed Gene Anatomy Database Constructed by Michael Ashburner	Oct 2000	egad2go
GenProtEC: E. coli Genome and Proteome functional categories Constructed by Heather Butler and Michael Ashburner	Dec 2000	genprotec2go
TIGRFAM: JCVI protein families JCVI (TIGRFAM) protein families Constructed by Michelle Gwinn and other TIGR staff	NA	tigrfams2go
JCVI roles JCVI roles Constructed by Michael Ashburner	Jan 2004	tigr2go
MIPS FunCat MIPS Functional Catalogue (FunCat) Constructed by Michael Ashburner and Midori Harris	NA	mips2go
MultiFun cell function assignment schema classifications Constructed by Michael Ashburner, Jane Lomax and Margrethe Hauge Serres	Dec 2005	multifun2go