Recent news

The UCL neurological gene annotation newsletter is now available at

We welcome Barbara Kramarz (nee Czub), who is moving from the Cardiovascular annotation team, and describe our continued focus on genes for which there is genetic evidence of a role in Parkinson’s.

Cardiovascular Gene Annotation Newsletter August 2016

The UCL cardiovascular gene annotation newsletter is now available at We describe our progress annotating miRs with GO, our recent bioinformatics training workshop and provide some information about our overseas visitor, Wafa Omer

Cardiovascular Gene Annotation Newsletter May 2016

The UCL cardiovascular gene annotation newsletter is now available at This newsletter highlights annotation of the miR-17~92 cluster, our RNA paper and our forthcoming 2-day bioinformatic resources workshop.

Paper on extending GO in the context of extracellular RNA and vesicle communication

To address the lack of standard terminology to describe extracellular RNA data and metadata, a team of several academic societies collaborated with the GO Consortium to extend the Gene Ontology with subcellular structure concepts relevant to the exRNA domain. As a result, exRNA data and metadata will be more easily annotated and queried because it will


The GO has historically provided access to annotations in a format called GAF (Gene Association Format). This format allows detailed representation of evidence and metadata for a GO term association, but has historically been limited in how well it can express important details of the cellular biology being described.

This has lead to a number of incremental improvements, while retaining compatibility, ultimately leading to the new expressive LEGO format.

Paper on GO-annotating key players in Parkinson's Disease published in Neuroinformatics

Read more about how we at UCL are using GO to annotate key players in Parkinson's disease. Our latest publication has just been published in Neuroinformatics:

Cardiovascular Gene Annotation Newsletter February 2016

The UCL cardiovascular gene annotation newsletter is now available at A new biocurator joins us this year, Barbara Czub, and we will be supervising 2 MSc student projects. In addition, Jess and Nancy have been annotating the telomere maintenance.

Connecting together multiple GO annotations: a report on the LEGO jamboree

In December, a group of us gathered at the Swiss Institute for Bioinformatics in Geneva to beta test and develop curation guidelines for a new GO annotation tool called Noctua. Noctua advances on the current GO annotation paradigm by allowing curators to connect together multiple annotations to give a cohesive picture of a biological process or mechanism.

To illustrate, consider the following two annotations which follow the current datamodel, which associates genes with GO terms:
  • TEM1 enables GTPase activity