Recent news

Cardiovascular Gene Annotation Newsletter February 2017

The UCL cardiovascular gene annotation newsletter is now available at https://www.ucl.ac.uk/functional-gene-annotation/cardiovascular/newslett... and summarises the aims of the new Alzheimer's project, suggests how to create a microRNA:mRNA network overlaid with GO terms @UCLGene

The UCL neurological gene annotation newsletter is now available at https://www.ucl.ac.uk/functional-gene-annotation/neurological/newsletter/Issue11

We welcome Barbara Kramarz (nee Czub), who is moving from the Cardiovascular annotation team, and describe our continued focus on genes for which there is genetic evidence of a role in Parkinson’s.

Cardiovascular Gene Annotation Newsletter August 2016

The UCL cardiovascular gene annotation newsletter is now available at http://www.ucl.ac.uk/functional-gene-annotation/cardiovascular/newslette.... We describe our progress annotating miRs with GO, our recent bioinformatics training workshop and provide some information about our overseas visitor, Wafa Omer

Cardiovascular Gene Annotation Newsletter May 2016

The UCL cardiovascular gene annotation newsletter is now available at https://www.ucl.ac.uk/functional-gene-annotation/cardiovascular/newslett.... This newsletter highlights annotation of the miR-17~92 cluster, our RNA paper and our forthcoming 2-day bioinformatic resources workshop.

Paper on extending GO in the context of extracellular RNA and vesicle communication

To address the lack of standard terminology to describe extracellular RNA data and metadata, a team of several academic societies collaborated with the GO Consortium to extend the Gene Ontology with subcellular structure concepts relevant to the exRNA domain. As a result, exRNA data and metadata will be more easily annotated and queried because it will

GAF, GPAD and LEGO

The GO has historically provided access to annotations in a format called GAF (Gene Association Format). This format allows detailed representation of evidence and metadata for a GO term association, but has historically been limited in how well it can express important details of the cellular biology being described.

This has lead to a number of incremental improvements, while retaining compatibility, ultimately leading to the new expressive LEGO format.

Paper on GO-annotating key players in Parkinson's Disease published in Neuroinformatics

Read more about how we at UCL are using GO to annotate key players in Parkinson's disease. Our latest publication has just been published in Neuroinformatics: http://www.ncbi.nlm.nih.gov/pubmed/26825309.