Recent news

Dec2018 UCL Functional Gene Annotation Newsletter

In the December issue of our newsletter ( we congratulate Rachael on her new position at SciBite. Rachael, we will miss you! We also provide a progress update on the GO annotation of microglial proteins and their regulatory microRNAs, and we summarise our participation and contribution to recent meetings.

UCL Functional Gene Annotation Newsletter

In the September issue of our newsletter ( we are pleased to make two exciting announcements. Ruth has been promoted to Professorial Research Fellow (Congratulations Professor Lovering!), whereas Rachael will be working on annotation of microRNAs involved in regulation of neuroinflammatory processes.

Cardiovascular Gene Ontology Annotation Newsletter July 2018
Our last Cardivascular newsletter ( provides an infographic ( describing the achievements the team has made over the past 10 years. From now on our quarterly newsletter will provide a summary of the work acheived by the whole team.

Announcement: Change in GO xrefs to Reactome

The GO is changing the identifiers used in Reactome cross-references (xrefs).

Currently we create xrefs IDs of the form "Reactome:REACT_XXXXX". These will be changed to canonical Reactome xrefs of the form Reactome:R-HSA-YYYYYY. An additional change is that we will only include xrefs to the human reaction, and will not include xrefs propagated to other species (let us know if you need these, and we can provide a method for obtaining these from Reactome).

Neurological Gene Ontology Annotation Newsletter July 2018

The July 2018 UCL neurological gene annotation newsletter is now available at

Neurological Gene Annotation Newsletter April 2018

The UCL neurological gene annotation newsletter is now available at The Neurological Gene Ontology Annotation Initiative represents a collaboration between University College London, the European Bioinformatics Institute (EBI), and University of Manchester, funded by Alzheimer's Research UK (grants ARUK-NSG2016-13 and ARUK-NAS2017A-1).

Published this week: Article describing the representation of autophagy in GO

A new article from GO Consortium members was published this week in the journal Autophagy.

Autophagy is a fundamental process used to recycle cellular components, respond to cellular stresses and remove foreign material from cells. Disruption of autophagy can lead to neurodegeneration, cardiac disease and cancer.

New paper on improving interpretation of cardiac phenotypes

Gene Ontology for Cardiac Conduction

Led by Ruth Lovering at University College London, the GO Consortium has collaborated with cardiovascular experts on a project to improve and expand the ontological representation of heart processes in the Gene Ontology. Subsequent literature curation using the new ontology terms has created a computational resource that can facilitate the interpretation of cardiac phenotypes.