The overall objective of the Parkinson’s UK Gene Ontology Project is to provide a unique public resource for the Parkinson's research community, both in the UK and internationally, by providing comprehensive functional annotation for genes implicated in neurological and immunological processes relevant to Parkinson's disease. High-throughput genomics and systems biology are particularly powerful tools for the investigation of multi-factorial phenotypes, such as Parkinson's disease. However, at the moment, systems biology approaches to dissect the neurological and immunological systems are severely hampered by the lack of functional annotation of many of the key gene products likely to be involved. Consequently this initiative will support a concentrated effort to improve the manual annotation of proteins involved in neurological and immunological systems using the Gene Ontology.
The improved annotation of these genes will ensure that the investment in genome sequencing along with the accumulated knowledge of neurological and immunological processes can be exploited to the full, for the benefit of researchers seeking to alleviate Parkinson's disease.
The Parkinson’s UK Gene Ontology Project is a collaborative project between the UniProt group at the European Bioinformatics Institute (EBI) and the Cardiovascular Genetics and Molecular Biology of Neurological Disease research groups at University College London (UCL). The annotations created as part of this project are listed with the 'source' PARL (Parkinson’s UK - University College London).
This project is supported by Parkinson's UK grant G-1307.